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整合素是一类普遍存在于细胞表面的跨膜糖蛋白 ,属于细胞粘附分子的一大家族。它参与细胞与细胞、细胞与细胞外基质的相互作用 ,在许多生理、病理过程中起着重要的作用。研究表明 ,哺乳动物卵子、精子表面均表达整合素 ,与受精过程有关。在月经周期的不同时期 ,子宫内膜表面表达的整合素种类和数量均不同 ,特别在月经黄体中期 ,其表达有特殊的变化 ,表明与子宫内膜的容受性及受精卵的植入相关。另外 ,它在胚胎的生长发育、不孕、流产等过程中也起重要作用。现对整合素在生殖领域的研究进展作一综述
Integrins are a class of transmembrane glycoproteins that are prevalent on the cell surface and belong to a large family of cell adhesion molecules. It participates in the interaction between cells and cells, cells and extracellular matrix, and plays an important role in many physiological and pathological processes. Research shows that mammalian eggs, sperm surface expression of integrins, and fertilization process. At different stages of the menstrual cycle, the type and number of integrins expressed on the surface of the endometrium are different, particularly in the mid-luteal phase of the menstruation, with specific changes that indicate endometrial receptivity and implantation of fertilized eggs . In addition, it also plays an important role in embryonic growth and development, infertility, abortion and other processes. Nowadays integrins in the field of reproductive research are reviewed