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目的对大连地区不同人群的HLA-DR/DQ基因型与乙型肝炎病毒(HBV)感染的相关性进行初步分析。方法利用微量聚合酶链反应-序列特异性引物(PCR-SSP)技术,分别检测乙型肝炎后肝硬化患者、乙型肝炎病毒携带者和正常对照人群的HLA-DR/DQ基因型。结果随机选择的乙型肝炎后肝硬化患者的HLA-DR7的抗原频率与正常对照人群比较显著升高(P<0·05);乙型肝炎病毒携带者的HLA-DQ8的抗原频率与正常对照人群比较显著升高(P<0·05);乙型肝炎后肝硬化患者与乙型肝炎病毒携带者比较,后者的HLA-DQ8抗原频率明显高于前者,差异有显著意义(P<0·05)。其它HLA等位基因频率在不同人群中差异无显著意义(P>0·05)。结论HLA-DR7/DQ8基因型与HBV感染之间可能存在一定相关性。
Objective To analyze the association between HLA-DR / DQ genotypes and hepatitis B virus (HBV) infection in different populations in Dalian. Methods HLA-DR / DQ genotypes were detected by polymerase chain reaction-sequence-specific primers (PCR-SSP) in patients with posthepatitic cirrhosis, hepatitis B virus carriers and normal controls. Results The frequency of HLA-DR7 antigen in patients with hepatitis B cirrhosis randomly selected was significantly higher than that in the normal controls (P <0.05). The frequency of HLA-DQ8 antigen in patients with hepatitis B virus infection was significantly higher than that in controls (P <0.05). The frequency of HLA-DQ8 antigen in patients with post-hepatitis B cirrhosis was significantly higher than that in patients with hepatitis B virus infection (P <0. 05) · 05). The frequencies of other HLA alleles in different populations had no significant difference (P> 0.05). Conclusion There may be some correlation between HLA-DR7 / DQ8 genotypes and HBV infection.