LC-MS/MS Method for Determination of Megestrol in Human Plasma and Its Application in Bioequivalence

• 作 者: 李帆 邹小娟 郑恒 向一
• 机 构: CollegeofPharmacy,DepartmentofPharmacy
• 出 处: Journal of Huazhong University of Science and Technology(Med
• 发表日期: 2013年6期
• 关键词: 生物等效性 人血浆 孕酮 应用 测定 S方法 LC-MS MS 多反应监测 megestrol bioequivalence liquid chromato
• 基金项目: This project was supported by the Foundation of the Zhejiang Xianju Pharmaceutical Co., Ltd （China）.

A rapid and highly selective liquid chromatography-tandem mass spectrometric(LC-MS/MS)method for the determination of megestrol in human plasma was described using medrysone as internal standard(IS).Blood samples were collected from 20 healthy volunteers