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目的探讨男性高尿酸血症(HUA)患者中成纤维细胞因子21(FGF21)水平与血尿酸(SUA)和IR的关系。方法在体检人群中选择男性高尿酸血症患者(HUA组)和健康者(NC组)各85名,HUA组以BMI水平分为HUA-高BMI亚组(n=41)及HUA-正常BMI亚组(n=44),分别检测FGF21、Hb A_1 c、BP、血脂、HOMA-IR等参数。结果 HUA组FGF21高于NC组[(1.99±0.96)vs(1.73±0.50)ng/ml,P<0.05];HUA-高BMI亚组FGF21水平高于HUA-正常BMI亚组[(2.04±3.61)vs(1.84±2.15)ng/ml,P<0.05];FGF21水平与BMI、WHR、TG、ln(HOMA-IR)、FIns、SUA呈正相关(r=0.456、0.355、0.231、0.257、0.220、0.222,P<0.05或P<0.01);多元线性逐步回归分析显示,WHR、SUA、ln(HOMA-IR)、TG是血清FGF21独立影响因素(P<0.05)。结论 FGF21在男性HUA患者中升高,且与SUA、1n(HOMA-IR)、BMI、WHR及脂代谢相关,其可能参与男性HUA患者的病理生理过程。
Objective To investigate the relationship between fibroblast growth factor (FGF21) and serum uric acid (SUA) and IR in male patients with hyperuricemia (HUA). Methods Eighty-five male patients with HUA and 85 healthy controls were enrolled in the study. The HUA group was divided into HUA-high BMI group (n = 41) and HUA-normal BMI Subgroups (n = 44). The parameters of FGF21, Hb A 1 c, BP, lipids and HOMA-IR were detected respectively. Results The FGF21 level in HUA group was significantly higher than that in NC group [(1.99 ± 0.96) vs (1.73 ± 0.50) ng / ml, P <0.05] (1.84 ± 2.15) ng / ml, P <0.05]. The level of FGF21 was positively correlated with BMI, WHR, TG, ln, FIns and SUA (r = 0.456,0.355,0.231,0.257,0.220, 0.222, P <0.05 or P <0.01). Multiple linear stepwise regression analysis showed that WHR, SUA, ln (HOMA-IR) and TG were the independent influential factors of serum FGF21 (P <0.05). Conclusions FGF21 is elevated in male patients with HUA, and is associated with SUA, 1n (HOMA-IR), BMI, WHR and lipid metabolism, which may be involved in the pathophysiological process of male HUA.