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目的定量评价某大型芳烃装置职业人群低水平苯接触致癌风险。方法选取某大型芳烃装置为研究对象,采用健康风险评价程序对苯长期低水平职业性接触下的致癌风险进行定量评价;其中,剂量-反应评价步骤中建立内剂量的剂量-反应评价多阶模型,风险表征步骤运用蒙特卡洛模拟方法得到职业接触人群在此环境下长期工作所存在的患癌风险概率。结果该芳烃装置工作场所空气中苯的短时间接触浓度为0.034 00~7.625 00(0.661 00±1.120 00)mg/m3,作业人员苯的内剂量拟合质量浓度为0.000 00~0.013 30(0.001 78±0.003 01)mg/m3,90%情况下其苯接触致癌风险低于4.747 7×10-5。结论该装置工人苯致癌风险超过美国国家环境保护局制定的人体可接受致癌风险,应采取相应措施降低风险。
Objective To quantitatively evaluate the carcinogenic risk of low level benzene exposure in occupational population of a large aromatic plant. Methods A large-scale aromatic hydrocarbon plant was selected as the research object. The health risk assessment program was used to quantitatively evaluate the carcinogenic risk of long-term low-level occupational exposure to benzene. In the dose-response evaluation procedure, an internal dose-response multi- The risk characterization step uses the Monte-Carlo simulation method to obtain the probability of cancer risk among occupationally exposed people working in this environment for a long time. Results The concentration of benzene in the air of the aromatic plant was 0.034 00-7.625 00 (0.661 00 ± 1.120 00) mg / m3, and the internal standard of benzene for workers was 0.000 00 ~ 0.013 30 (0.001 78 ± 0.003 01) mg / m3, 90% benzene exposure to carcinogenic risk less than 4.747 7 × 10-5. CONCLUSIONS The workers’ benzene carcinogenic risk exceeds the acceptable carcinogenic risk of the human body set by the U.S. National Environmental Protection Agency. Corresponding measures should be taken to reduce the risk.