论文部分内容阅读
目的观察短期胰岛素联合降糖药物强化治疗社区初诊2型糖尿病的疗效。方法选取本院自2012年9月—2014年9月收治的80例初诊2型糖尿病患者作为研究对象,随机分为对照组与观察组各40例。对照组给予降糖药物口服治疗,观察组则联用短期胰岛素强化治疗,2组均治疗4周,比较治疗前后2组患者FBG、Hb Alc、2 h PG、空腹胰岛素(fasting insulin,FINS)、胰岛素抵抗指数(HOMA-IR)及胰岛素分泌指数(HOMA-β)等指标的变化情况。计量资料采用t检验,P<0.05为差异有统计学意义。结果治疗后,观察组HOMA-IR[(1.0±0.1)]、HOMA-β[(-2.3±1.6)]与对照组[(1.5±0.3)、(-3.8±2.0)]比较,差异有统计学意义(P<0.05)。结论在社区初诊2型糖尿病患者的临床治疗中,应用口服降糖药物联合短期胰岛素强化治疗,可纠正患者的血糖指标,强化胰岛素β细胞功能,降低胰岛素抵抗程度,短期疗效显著,值得推广。
Objective To observe the efficacy of short-term insulin combined with hypoglycemic agents in the treatment of newly diagnosed type 2 diabetes in community. Methods Eighty newly diagnosed type 2 diabetic patients admitted from September 2012 to September 2014 in our hospital were randomly divided into control group and observation group of 40 cases. The control group was treated with oral glucose-lowering drugs. The observation group was treated with short-term insulin-intensive therapy. The two groups were treated for 4 weeks. FBG, Hb Alc, 2 h PG, fasting insulin (FINS) Insulin resistance index (HOMA-IR) and insulin secretion index (HOMA-β) and other indicators of changes. Measurement data using t test, P <0.05 for the difference was statistically significant. Results After treatment, HOMA-IR [(1.0 ± 0.1)] and HOMA-β [(-2.3 ± 1.6)] in the observation group were significantly lower than those in the control group [(1.5 ± 0.3) and (-3.8 ± 2.0) Significance (P <0.05). Conclusions In the clinical treatment of patients with newly diagnosed type 2 diabetes in community, oral hypoglycemic agents combined with short-term intensive insulin therapy can correct the patients’glycemia index, strengthen the function of insulin β-cells and reduce the degree of insulin resistance. The short-term curative effect is worthy of promotion.