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Objective:To investigate the relationship between dynamic contrast-enhanced MRI parameters and tumor angiogenesis in peripheral pulmonary adenocarcinoma. Methods :Thirty-seven patients with pathologic proved pulmonary adenocarcinoma underwent dynamic contrast-enhanced MR Imaging. Microvessel density(MVD) was counted and vascular endothelial growth factor(VEGF) expression was assessed with immunohistochemical method. Dynamic contrast-enhanced MRI-derived parameters, such as peak height(PH), steepest slope (SS), maximum enhancement rate (Emax) ,enhancement rate at 1-6 minutes (E1-6), were calculated and compared with MVD in pulmonary adenocarcinoma. And the parameters were also compared between VEGF-positive and VEGF-negative pulmonary adenocarcinoma. Results : The microvessel density was 68.31±19.84 in 37 pulmonary adenocarcinoma. The PH, SS, Emax E1-6 correlated positively with MVD respectively(P＜0.001). The strongest relationship was found between SS and MVD(r= 0. 827,P＜0.001). There was a significant difference between MVD of VEGF-positive pulmonary adenocarcinoma (79. 47±21.35) and MVD of VEGF-negative pulmonary adenocarcinoma (43.16 ±17.85) (P＜0.001). All the parameters in VEGF-positive pulmonary adenocarcinoma were higher than those in VEGF-negative pulmonary adenocarcinao (P＜0.001 ). Conclusion: Dynamic contrast-enhanced MRI-derived parameters of pulmonary adenocarcinoma correlated positively with MVD. The parameters in VEGF-positive pulmonary adenocarcinoma were higher than those in VEGF-negative pulmonary adenocarcinoma (P＜0.001 ).