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目的探讨危重病患者医院内深部真菌感染的易感因素与防治对策。方法回顾性分析重症监护病房(ICU)内60例深部真菌感染的危重病患者的临床资料。结果深部真菌感染除了与患者的年龄和原发病有关外,还与长期住院、广谱抗生素和糖皮质激素的使用、大型手术以及各种侵入性操作和全肠外营养的广泛开展等有密切关系。结论合理使用抗生素和糖皮质激素,减少不必要的侵入性操作,加强全身营养支持,改善肠道微生态平衡,密切检测,及早治疗,可以改善深部真菌感染的危重病患者的预后。
Objective To explore the susceptible factors and control strategies of deep fungal infection in critically ill patients in hospitals. Methods The clinical data of 60 critically ill patients with deep fungal infection in intensive care unit (ICU) were retrospectively analyzed. Results Deep fungal infection was not only related to age and primary disease, but also to long-term hospitalization, use of broad-spectrum antibiotics and glucocorticoids, large-scale surgery, and extensive invasive parenteral nutrition and parenteral nutrition relationship. Conclusion The rational use of antibiotics and glucocorticoids, reduce unnecessary invasive operations, enhance systemic nutritional support, improve intestinal microflora balance, close detection and early treatment, can improve the prognosis of critically ill patients with deep fungal infection.