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目的 :研究肾小球滤过膜对不同分子量蛋白质通透性能对苯那普利短期治疗的反应性。方法 :根据聚丙烯酰胺凝胶电泳和 2 4小时尿蛋白定量 ,计算出大分子量和中分子量尿蛋白排泄量。口服苯那普利 10mg/d ,共两天 ,测定用药前后2 4小时尿蛋白总量、尿蛋白圆盘电泳、平均动脉血压等。结果 :用药后大分子尿蛋白、平均动脉血压明显降低 ( 1.15± 0 .89)g/ 2 4hvs ( 0 .84± 0 .74)g/h ,P <0 .0 1;( 14 .19± 1.96)kPavs ( 12 .76± 1.12 )kPa ,P <0 .0 1) ,2 4小时尿蛋白总量、中分子尿蛋白数减少无显著性 ( 3 .16± 2 .2 4)g/ 2 4hvs ( 2 .83± 2 .2 7) g/ 2 4h ,P >0 .0 5 ;( 1.72± 1.2 2 )g/ 2 4hvs ( 1.62± 1.47) g/ 2 4h ,P >0 0 5 )。结论 :短期使用苯那普利可改善肾小球滤过膜对大分子蛋白的通透性。
OBJECTIVE: To study the reactivity of glomerular filtration membrane to the short-term treatment of benazepril with different molecular weight protein permeability. Methods: Based on polyacrylamide gel electrophoresis and 24-hour urine protein quantitation, large and medium molecular weight urinary protein excretion was calculated. Oral benazepril 10mg / d, a total of two days, 24 hours before and after treatment to determine the total amount of urine protein, urine protein disk electrophoresis, mean arterial blood pressure. Results: Urine protein and mean arterial blood pressure decreased significantly after treatment (1.15 ± 0.89) g / 2 4hvs (0.84 ± 0.74) g / h, P <0.01; (14.19 ± 1.96) kPavs (12.76 ± 1.12) kPa, P <0.01). There was no significant decrease in urinary protein in 24 hours (3.16 ± 2.24) g / 2 4hvs (2.83 ± 2.27) g / 2 4h, P> 0.05; (1.72 ± 1.2 2) g / 2 4hvs (1.62 ± 1.47) g / 2 4h, P> 0.05). Conclusion: Short-term use of benazepril improves glomerular filtration membrane permeability of macromolecular proteins.