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甲壳素(Chitin)[(1→4)-2-乙酰胺基-2-脱氧-β-D-葡萄糖]和聚甲壳醣(Chitosan)[(1→4)-2-氨基-2-脱氧-β-D-葡萄糖]无生物损害,在医学上已有应用,如用甲壳素作为一种抗凝血剂和创伤愈合的促进剂。聚甲壳醣曾用来作为人工肾膜。但它们在药剂学领域中应用极少。本文采用这二种材料和消炎痛、罂粟碱盐酸盐分别制成缓释凝胶剂,研究其释药情况。干燥甲壳素凝胶的制备:取甲壳素200mg溶于8ml六氟-2-丙醇中。经200w超声波处理1小时,室温静置过夜。将药物100mg溶于溶剂中,再与上述溶液混匀。取该液约3ml置于称重的瓶中(直径1.5cm,长2 cm)。于60℃蒸发溶剂5小时,真空干燥
Chitin [(1 → 4) -2-acetamido-2-deoxy-β-D-glucose] and Chitosan [(1 → 4) β-D-glucose] has no biological damage, has been used in medicine, such as the use of chitin as an anticoagulant and wound healing promoter. Chitosan has been used as an artificial kidney membrane. But they are rarely used in pharmacy. In this paper, these two kinds of materials and indomethacin, papaverine hydrochloride were made of sustained release gel, the study of its release. Preparation of dry chitin gel: Chitin 200mg dissolved in 8ml hexafluoro-2-propanol. After 200w ultrasonic treatment for 1 hour, let stand overnight at room temperature. The drug 100mg dissolved in the solvent, and then mix with the solution. About 3 ml of this solution was taken in a weighing bottle (1.5 cm in diameter and 2 cm in length). The solvent was evaporated at 60 ° C for 5 hours and dried in vacuo