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采用CD34单克隆抗体QB－END／10免疫组织化学SP法检测了68例胃癌组织中的微血管密度（MicrovesseldensityMVD），旨在探讨肿瘤血管生成在胃癌侵袭、转移和预后判断中的意义。结果发现，所有胃癌组织中平均MVD为18．2土10．9，MVD随肿瘤侵袭深度、TNM分期的增加而增大，有淋巴结转移患者的MVD（20．85士10．19）明显高于无淋巴结转移患者（14．32土10．67）（P＜0．01）。有血管、神经侵犯的胃癌患者MVD明显高于无血管、神经侵犯者（P＜0．01）。单因素、多因素分析表明，高MVD（≥18）胃癌患者比低MVD（＜18）患者预后明显为差（P＜O．05），MVD是影响胃癌预后的独立因素。研究表明，肿瘤血管生成是胃癌侵袭、转移发生必不可少的环节，MVD是衡量胃癌细胞侵袭转移能力和判断患者预后的一个有用指标。
The microvessel density (MVD) in 68 cases of gastric cancer tissues was detected by the CD34 monoclonal antibody QB-END/10 immunohistochemistry SP method to investigate the significance of tumor angiogenesis in invasion, metastasis, and prognosis of gastric cancer. The results showed that the average MVD in all gastric cancer tissues was 18.2 soil and 10.9. The MVD increased with the depth of tumor invasion and TNM stage, and the MVD of patients with lymph node metastasis was significantly higher (20.85±10.19). Patients without lymph node metastasis (14.32 soil 10.67) (P < 0.01). The MVD in patients with gastric cancer and nerve invasion was significantly higher than those without avascular or nerve invasion (P<0.01). Univariate and multivariate analysis showed that the prognosis of patients with high MVD (≥18) gastric cancer was significantly lower than that of patients with low MVD (<18) (P<0.05). MVD was an independent factor influencing the prognosis of gastric cancer. Studies have shown that tumor angiogenesis is an indispensable link in the invasion and metastasis of gastric cancer. MVD is a useful indicator to measure the invasion and metastasis of gastric cancer cells and to determine the prognosis of patients.