头颈部真皮发生胸腺样分化癌

• 作 者: Bayer-Garner I.B. Kozovska M.E.tz M.R. 张宪旗
• 机 构: Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, United States Dr.
• 出 处: 世界核心医学期刊文摘(皮肤病学分册)
• 发表日期: 2005年02期
• 关键词: 胸腺 颈部 真皮 颈部软组织 淋巴上皮样癌 甲状腺 鳞癌 原发部位 胸腺组织 颚角

Carcinoma exhibiting thymus-like differentiation (CASTLE) is a rare, distinct tumor of the thyroid gland or soft tissue of the head and neck that may simulate primary squamous cell carcinoma or lymphoepithelioma, and which contains features reminiscent of thymic differentiation including Hassall’s corpuscles, occasional perivascular spaces, and the presence of lymphocytes. Ectopic thymic tissuemay result fromincomplete descent or persistence of the cervical portion of the thymus and may occur anywhere along the course of the embryonic descent from the angle of the mandible to the sternal notch. Herein, we report two cases of dermal extrathyroidalCASTLE. The differential diagnosis of squamoid carcinoma with features of thymic differentiation includes extrathyroidal CASTLE, a primary squamous cell carcinoma with thymic differentiation, lymphoepithelioma-like carcinoma of the skin, and metastatic squamous cell carcinoma of unknown primary. It is essential that the latter two be ruled out before accepting the diagnosis of an extrathyroidal carcinoma with thymus-like differentiation.

Carcinoma exhibiting thymus-like differentiation (CASTLE) is a rare, distinct tumor of the thyroid gland or soft tissue of the head and neck that may simulate primary squamous cell carcinoma or lymphoepithelioma, and which contains features reminiscent of thymic differentiation including Hassall’s corpuscles, occasional perivascular spaces, and the presence of lymphocytes. Ectopic thymic tissuemay result fromincomplete descent or persistence of the cervical portion of the thymus and may occur anywhere along the course of the embryonic descent from the angle of the mandible to the sternal notch. Herein, we report The differential diagnosis of squamous carcinoma with features of thymic differentiation includes extrathyroidal CASTLE, a primary squamous cell carcinoma with thymic differentiation, lymphoepithelioma-like carcinoma of the skin, and metastatic squamous cell carcinoma of unknown primary. It is essential that the latter two be ruled out before accepting the diagnosis of an extrathyroidal carcinoma with thymus-like differentiation.