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目的:探讨男性血清抗苗勒管激素(AMH)对精液质量及人工助孕妊娠结局的预测价值。方法:103例行卵细胞质内单精子注射(ICSI)治疗的男性患者,分为精子浓度正常组(29例)、少精子症组(27例)、梗阻性无精子症组(29例)和非梗阻性无精子症组(18例),采用ELISA法检测男性血清AMH及其他相关性激素水平,结合其取精当天精液质量及助孕后妊娠结局进行分析。结果:①4组不同精液质量血清AMH含量分别为(5.03±0.44)、(3.70±0.44)、(5.39±0.71)、(7.31±1.64)pmol/L,差异无显著性(F=2.02,P=0.12)。②103对夫妇卵子受精率为(76.13±23.66)%,与男方血清AMH水平无显著性相关(P>0.05)。③妊娠与非妊娠组男方血清AMH含量分别为(6.19±1.05)、(4.72±0.37)pmol/L,差异无显著性(P>0.05)。结论:男性血清AMH水平不能反映其生精状况,亦不能预测其ICSI助孕后的卵子受精率及妊娠结局,故不能单独作为ICSI助孕结局的血清学标志物。
Objective: To investigate the predictive value of serum anti-Mullerian hormone (AMH) on the quality of semen and pregnancy outcome of artificial pregnancy. Methods: A total of 103 male patients with intracytoplasmic sperm injection (ICSI) were divided into normal sperm concentration group (n = 29), oligozoospermia group (n = 27), obstructive azoospermia group (n = 29) Non-obstructive azoospermia group (n = 18). Serum levels of AMH and other related hormones were measured by ELISA. The quality of semen and the pregnancy outcome after pregnancy were analyzed. Results: (1) There was no significant difference in serum AMH levels among the four groups (5.03 ± 0.44, 3.70 ± 0.44, 5.39 ± 0.71, 7.31 ± 1.64 pmol / L, respectively) 0.12). ② The egg fertilization rate of 103 couples was (76.13 ± 23.66)%, which had no significant correlation with serum AMH level in men (P> 0.05). (3) There was no significant difference in serum AMH level between male and nonpregnant men (6.19 ± 1.05) and (4.72 ± 0.37) pmol / L, respectively (P> 0.05). Conclusion: Serum AMH levels in males do not reflect their spermatogenic status, nor can they predict the fertilization rate and pregnancy outcome of their fertilized ICSI. Therefore, they should not be used as a serological marker for ICSI pregnancy outcomes alone.