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通过对急性胰腺炎（AP）患者体内中等长度DD片段的检测，进一步证实AP患者止凝血系统的变化及意义。选择AP患者94例（其中MAP 42例、SAP 52例），健康对照组50名。收集血常规，凝血指标（PT），活化的部分凝血活酶时间（APTT），纤维蛋白原（FIB）及D-二聚体（D-dimmer），生化指标（肝、肾功能，血糖，血钙），血气分析，血、尿淀粉酶，腹部B超以及腹部CT检查等情况，计算出入院24h内的APACHEⅡ评分。最终得出结论：1.SAP患者中凝血、纤溶系统被激活。2.APACHEⅡ评分较为繁琐而且耗时较长，而中等片段的DD指标可以更好地反映病情以及未来的预后。3.关注AP患者止凝血系统的变化，有助于了解AP患者微循环障碍情况，为临床纠正凝血功能紊乱，改善预后提供依据，以提高AP治愈率。“,”Based on the detection of medium length DD fragment of the patients with acute pancreatitis(AP) in vivo,we want to confirmed the changes and significance of coagulation system in AP patients.We choose 94 cases with AP(MAP 42,SAP 52),and healthy control group of 50 cases;and collected blood routine,PT,APTT, FIB and D-dimer,biochemical index(liver and renal function,blood glucose,serum calcium),blood gas analysis,blood and urine amylase,abdominal B ultrasound and abdominal CT examination etc.,computing hospital within 24h of APACHEⅡscore.Final conclusion:1.In SAP patients,coagulation and ifbrinolytic system is activated;2.The score of APACHEⅡis more complex and time consuming,and secondary fragments of the DD index can better relfect the illness and the prognosis for future;3.Paying attention to the coagulation system changes of AP patients,will contribute to the understanding of AP microcirculation in patients with clinical situation,for the correction of coagulation disorders,improve prognosis and improve the cure rate of AP.