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目的 探讨子宫平滑肌瘤与雌、孕激素受体和表皮生长因子受体的关系 ,了解三者在肌瘤、包膜和正常肌组织间的表达情况。方法 采用免疫组化LSAB法。结果 ER、PR和EGFR阳性面积在瘤旁、包膜及肌瘤区差异均非常显著 ,其中瘤旁与包膜间差异均不显著 ,而肌瘤区与瘤旁和包膜间差异均极显著。结论 ①雌、孕激素对子宫平滑肌瘤的发生均有一定作用。表皮生长因子对它的发生、发展可能也有一定的影响 ;②子宫平滑肌瘤剔除术切除包膜与否对肌瘤的复发不一定存在正相关关系。
Objective To investigate the relationship between uterine leiomyoma and estrogen and progesterone receptors and epidermal growth factor receptor (EGFR), and to understand the expression of these three proteins in myomas, envelopes and normal muscle tissues. Methods Immunohistochemical LSAB method. Results The positive areas of ER, PR and EGFR were significantly different in the tumor side, the capsule and the myoma region, and the difference between the tumor side and the capsule was not significant, while the difference between the myoma region and the tumor side and the capsule was extremely significant . Conclusion ① Estrogen and progesterone have some effect on the occurrence of uterine leiomyomas. Epidermal growth factor on its occurrence and development may also have a certain impact; ② uterine leiomyoma resection of the envelope or not on the recurrence of fibroids is not necessarily a positive correlation.