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腰椎间盘突出症是临床常见病、多发病,发病率约为20%~30%[1].然而椎间盘突出症的生物学机制尚不明确,构建与人类疾病相关性、可比性较高的椎间盘突出的动物模型是研究该病的基础和关键。近年来,国内外报道的椎间盘突出模型分为在体模型和体外模型,而动物在体模型是基础研究成果过渡到临床所必须跨越的研究阶段。1实验诱导椎间盘突出动物模型1.1直接损伤模型1.1.1终板损伤模型Moon等[2]通过在家兔椎体
Lumbar disc herniation is a common clinical disease, frequently-occurring disease, the incidence rate of about 20% to 30% [1] However, the biological mechanism of disc herniation is not clear, to build and human disease-related, comparable high intervertebral disc Prominent animal model is the basis and key to study the disease. In recent years, disc herniation models reported at home and abroad are divided into in vivo models and in vitro models, while animal in vivo models are the research stages that must be crossed to transition from basic research results to clinical ones. 1 experimental induced disc herniation animal model 1.1 direct injury model 1.1.1 endplate injury model Moon et al [2] in the rabbit vertebral body