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Ernest Goodpasture 于1919年报告了首例患者在流感后咯血、贫血、死亡,尸解证实肺泡出血、坏死及肾炎.此后65年中又有500余例类似病例报道.1958年 Stanton 及 Tange 首先建议将其命名为 Goodpasture 综合征.文献中它还被称为肺出血—肾炎综合征及出血性肺—肾综合征等.1967年 Lerner 等证实在肺出血合并肾炎病例中相当一部份是由抗肾小球基膜(GBM)抗体致病,此后多数作者都主张将 Goodpasture 综合征的命名严格限制在这部份病例中.因此,本文所指肺出血—肾炎综合征应必备下列三个条件:(1)肺出血;(2)肾小球肾炎;(3)抗 GBM 抗体形成.病理改变一、肾脏病变:光镜下典型表现为新月体性肾炎.该新月体性肾炎之特点为不伴肾小球毛细血管
Ernest Goodpasture reported the first case of hemoptysis, anemia, death, and autopsy confirmed alveolar hemorrhage, necrosis, and nephritis after the flu in 1919. There were more than 500 similar cases reported in 65 years since 1958. Stanton and Tange first proposed It is named Goodpasture syndrome in the literature it is also known as pulmonary hemorrhagic nephritis syndrome and hemorrhagic lung-renal syndrome, etc. 1967 Lerner et al confirmed that a considerable part of the cases of pulmonary hemorrhage with nephritis by the anti-kidney Most of the authors advocate that the naming of Goodpasture syndrome be strictly limited to this part of the case.Therefore, this article refers to the pulmonary hemorrhagic nephritis syndrome should have the following three conditions: (1) pulmonary hemorrhage; (2) glomerulonephritis; (3) the formation of anti-GBM antibody pathological changes of a kidney disease: light microscopy typical of crescentic glomerulonephritis.The crescentic glomerulonephritis is characterized by Not with glomerular capillaries