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本研究旨在阐明肝纤维化与门脉高压的关系,以及后向血流学说与前向血流学说间的内在联系。结果表明:肝纤维化程度与门脉高压增高幅度及侧枝循环开放有密切关系。肝纤维束宽度为469.3±137.5μm时,门脉压为1.91±0.23kPa,无侧枝循环开放及(或)腹水形成;肝纤维束宽度为806.02±125.6μm时,门脉压为2.54±0.37kPa,出现侧枝循环开放及(或)腹水形成。肝纤维束宽度与门脉高压的相关系数(γ)为0.685(P<0.05),提示后向血流学说是门脉高压症的发病基础。
The purpose of this study was to elucidate the relationship between liver fibrosis and portal hypertension, as well as the interrelationship between posterior flow theory and anterior flow theory. The results showed that the degree of hepatic fibrosis was closely related to the increase of portal hypertension and the opening of collateral circulation. The portal vein pressure was 1.91 ± 0.23 kPa at 469.3 ± 137.5 μm and no collateral circulation and / or ascites were formed. When the width of liver fiber bundle was 806.02 ± 125.6 μm, the portal pressure was 2.54 ± 0.37 kPa , There collateral circulation open (or) ascites formation. The correlation coefficient (γ) between the width of hepatic fibrosis and portal hypertension was 0.685 (P <0.05), suggesting that the posterior flow theory is the pathogenesis of portal hypertension.