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碳酸氢钠是纠正代谢性酸中毒最符合生理性的药物。但由于它在水中溶解度低,与Ca~(2+)、Mg~(2+)能产生碳酸钙、碳酸镁沉淀,故碳酸氢钠血透析液很不稳定,往往配制后2小时就产生沉淀,造成透析器管道阻塞,临床应用受到限制。近年来,由于研究成功碳酸氢钠透析液供给器,使得碳酸氢钠透析液又重新被重视而应用于临床。我院自1980年以来,改进该透析液配制方法,加入少量乳酸,使透析液的pH降至7.3～7.6,增加了稳定性,不阻塞透析器的管道。现将配制方法作一介绍。 1.处方 A液(浓缩液):氯化钠25.59g,氯化钾药学通报1984年第19卷第6期
Sodium bicarbonate is the most physiologically correct drug to correct metabolic acidosis. However, due to its low solubility in water, and Ca ~ (2 +), Mg ~ (2+) can produce calcium carbonate, magnesium carbonate precipitation, so the sodium bicarbonate hemodialysis is very unstable, often formulated 2 hours after precipitation , Resulting in dialyzer tube obstruction, clinical application is limited. In recent years, due to the successful study of sodium bicarbonate dialysate supply, making sodium bicarbonate dialysate re-attention and applied to clinical. Since 1980, our hospital has improved the preparation method of dialysate and added a small amount of lactic acid to reduce the pH of dialysate to 7.3 ~ 7.6, which increases the stability and does not block the dialysis tube. Now the preparation method for an introduction. 1. Prescription A liquid (concentrate): 25.59g of sodium chloride, potassium chloride Pharmaceutical Bulletin 1984 Volume 19 No. 6