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对正常妇女的临床观察表明,使用药用剂量的LRF及其高活性类似物(LRF-Ag),可抑制排卵和诱发功能性的黄体溶解。鉴于LRF对鼠可直接作用于卵巢抑制促性腺激素的作用。作者研究了这种可能性,即LRF及其LRF-Ag也直接抑制人颗粒细胞的FSH-媒介类固醇形成作用。人卵泡是从7例正常妇女(年龄35～46岁,在月经周期滤泡期未受伤的卵巢或卵巢楔形活检时获得的,另一侧取自于多囊卵巢综合征患者。全部病
Clinical observations of normal women show that the use of a pharmaceutically acceptable dose of LRF and its highly active analog (LRF-Ag) inhibits ovulation and induces functional luteal lysis. In view of LRF mouse can directly affect ovarian suppression of gonadotropin. The authors investigated the possibility that LRF and its LRF-Ag also directly inhibit FSH-mediated steroidogenesis in human granulosa cells. Human follicles were obtained from 7 normal women (age 35-46 years old with ovarian or ovarian wedge biopsy at the follicular phase of the menstrual cycle and on the other side from polycystic ovary syndrome.