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目的:探讨血清脂蛋白a[LP(a)]与糖尿病肾病(DN)的关系。方法:根据尿白蛋白排泄率(UAER)将86例2型糖尿病(DM)患者分为单纯糖尿病(SDM)组、早期糖尿病肾病(EDN)组和临床糖尿病肾病(CDN)组,30例门诊健康体检者作为正常对照组(NC)。分别检测各组血清LP(a)的水平,并与正常对照组进行比较。结果:LP(a)水平SDM组、EDN组、CDN组显著高于NC组,与NC组比较差异有统计学意义(P<0.01)。LP(a)与UAER呈显著正相关(r=0.485)。结论:EDN组、CDN组患者血清LP(a)水平随着UAER的增加而升高,可能与DN的进展有关。
Objective: To investigate the relationship between serum lipoprotein a [LP (a)] and diabetic nephropathy (DN). Methods: Eighty-six patients with type 2 diabetes mellitus (DM) were divided into two groups according to urinary albumin excretion rate (UAER): SDM group, EDN group and CDN group, 30 outpatients Physical examination as a normal control group (NC). The level of serum LP (a) in each group was detected and compared with the normal control group. Results: The levels of LP (a) in SDM, EDN and CDN groups were significantly higher than those in NC group (P <0.01). There was a significant positive correlation between LP (a) and UAER (r = 0.485). Conclusion: The level of LP (a) in EDN group and CDN group increased with the increase of UAER, which may be related to the progression of DN.