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本实验探讨了家兔肠缺血再灌流损伤时肠外器官损害的发生机制，观察了虎杖甙对器官的保护作用。结果显示，与肠缺血再灌流损伤组相比较，虎杖甙处理组动物肺通透指数上升的幅度显著降低。虎杖甙处理组动物肠、肺、肝和肾中ＭＤＡ含量也较肠缺血再灌流组显著降低。虎杖甙处理组动物肺和肾中ＳＯＤ含量显著高于肠缺血再灌流损伤组。虎杖甙还可以减少肿瘤坏死因子和溶酶体酶Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶的释放。实验表明虎杖甙具有抑制脂质过氧化反应，稳定溶酶体膜和减少肿瘤坏死因子释放的作用，因而可以减轻肠缺血再灌流引起的肠和肠外器官的损害。
This experiment explored the mechanism of intestinal organ damage during intestinal ischemia-reperfusion injury in rabbits and observed the protective effect of Polygonum cuspidatum on organs. The results showed that compared with the intestinal ischemia-reperfusion injury group, the increase in lung permeability index in the Polygonum cuspidatum group was significantly reduced. The contents of MDA in the intestine, lung, liver, and kidney of the Polygonum cuspidatum group were also significantly lower than those of the intestinal ischemia-reperfusion group. The SOD content in the lungs and kidneys of the Polygonum cuspidatum group was significantly higher than that of the intestinal ischemia-reperfusion injury group. Polygonum cuspidatum can also reduce the release of tumor necrosis factor and lysosomal enzyme N-acetyl-β-D-glucosaminidase. Experiments have shown that Polygonum cuspidatum has the effects of inhibiting lipid peroxidation, stabilizing lysosomal membranes, and reducing the release of tumor necrosis factor, which can reduce intestinal and extra-intestinal organ damage caused by intestinal ischemia and reperfusion.