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多重乳剂已有较长的历史,但有目的地研究是近十多年才开始的,目前研究较多的是水包油包水(W/O/W)型。这种剂型在医药上作为药物控制释放系统,用于癌症治疗具有高效、长效和定位的作用;还可用于药物超剂量处理,显示出“液体膜”的特殊性能,应用上有较大潜力。多重乳剂的制备多采用二步乳化法,不少研究者探索了影响多重乳剂形成的各种因素;同时,为获得稳定制品,在稳定性评价方法、影响稳定性因素和增加稳定性措施等方面作了一些研究。
Multiple emulsions have a long history, but a purposeful study started in the last ten years or so. Currently, more studies have focused on W / O / W. This dosage form is used as a drug controlled release system in medicine for the treatment of cancer with high efficiency, long-lasting and positioning effect. It can also be used for drug overdosing treatment, showing the special properties of “liquid membrane” Great potential. Multiple emulsions are mostly prepared by two-step emulsification method. Many researchers have explored various factors that affect the formation of multiple emulsions. In the meantime, in order to obtain stable products, the methods of stability assessment, stability factors and stability measures Made some research