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目的探讨血脂和载脂蛋白A1、B与急性脑梗死的关系。方法选择160例急性脑梗死(ACI)患者,测定血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及载脂蛋白A1(apoA1)和载载脂蛋白B(apoB)水平的变化,与对照组进行比较;并对病情的严重程度与血脂水平的关系进行探讨。结果急性脑梗死组患者血清TG、TC和LDL-C均比对照组显著为高(P<0.05或P<0.01),但HDL-C、apoB水平较对照组显著降低(P<0.01和0.05)。中、重型组的TG、TC、HDL-C、LDL-C、apoB和重型apoA、水平与轻度组相比,差异均有极显著性(P<0.01或0.05);与中型组相比,重型组的TG、TC、HDL-C、apoB水平均有显著性变化(P<0.05或0.01),但LDL-C、apoA无显著性变化。结论血脂和与载脂蛋白A1、B水平与急性脑梗死的发病和病情及预后有密切的关系。
Objective To investigate the relationship between serum lipids, apolipoproteins A1 and B and acute cerebral infarction. Methods 160 patients with acute cerebral infarction (ACI) were enrolled in this study. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) (ApoA1) and apolipoprotein B (apoB) levels were compared with the control group; and the relationship between the severity of the disease and the level of blood lipid was also discussed. Results Serum levels of TG, TC and LDL-C in patients with acute cerebral infarction were significantly higher than those in the control group (P <0.05 or P <0.01), but the levels of HDL-C and apoB were significantly lower than those in the control group (P <0.01 and 0.05) . The levels of TG, TC, HDL-C, LDL-C, apoB and heavy apoA in the moderate and severe groups were significantly higher than those in the mild group (P <0.01 or 0.05) The levels of TG, TC, HDL-C and apoB in severe group had significant changes (P <0.05 or 0.01), but there was no significant change in LDL-C and apoA. Conclusion Serum lipids are closely related to the pathogenesis and prognosis of acute cerebral infarction with apolipoprotein A1 and B levels.