论文部分内容阅读
本文应用小剂量干扰素,从1个月至6个月不同疗程治疗97例HBsAg阳性伴HBeAg阳佳60例慢性乙型肝炎病人,以HBsAg、HBeAg、抗-HBe、HBcAg、DNAP和HBV-DNA 6项作为抗病毒指标,经1个月疗程97例,6项指标均无明显改善,经2个月疗程77例,只有DNAP阳性率下降和HBeAg阳性下降明显,经3个月疗程60例,5项病毒指标(除HBV-DNA外)均有统计学意义的下降,经6个月疗程42例,5项病毒指标阳性率稳定下降,下降缓慢的HBV-DNA(从73.24％下降为23.1％)和HBsAg(从100％下降为50％)也明显下降。这些病毒指标中以DNAP和HBeAg最敏感,次为HBcAg,再为HBV-DNA,最不敏感是HBsAg。本结果表明小剂量干扰素有抑制乙肝病毒复制怍用,长疗程(3个月以上)优于短程。
In this paper, a small dose of interferon, from 1 month to 6 months of different courses of treatment of 97 cases of HBsAg positive HBeAg positive with 60 cases of chronic hepatitis B patients with HBsAg, HBeAg, anti-HBe, HBcAg, DNAP and HBV-DNA 6 as an antiviral index, after a course of 97 months of treatment, no significant improvement in six indicators, after 2 months of treatment of 77 cases, only DNAP positive rate decreased and HBeAg positive decreased significantly after 60 courses of treatment in 3 months, Five viral markers (except HBV-DNA) had statistically significant decrease. After 6 months of treatment, 42 cases showed a steady decrease in the positive rate of 5 viral markers, and a slow decline of HBV DNA (from 73.24% to 23.1% ) And HBsAg (from 100% to 50%) also decreased significantly. The most sensitive of these virus markers are DNAP and HBeAg, the second is HBcAg, the second is HBV-DNA, and the least sensitive is HBsAg. The results show that small doses of interferon can inhibit hepatitis B virus replication, long course (more than 3 months) is better than short range.