论文部分内容阅读
正畸牙移动是压力侧骨吸收和张力侧骨形成动态平衡的骨改建过程。在机械力诱导下成骨细胞、破骨细胞等发生相应的功能的变化。具有多向分化潜能的骨髓基质干细胞(bone mesenchymal stem cells,BMSCs)为力学敏感细胞,在体外适当机械刺激下,其生物学特性发生功能性变化,适应性应答力学刺激的最佳要求,表现为成骨分化,此过程需多种信号分子。作为一种转录因子,信号转导和转录活化因子3(signal transducer and activator of transcription 3,STAT3)可参与细胞增殖、分化、存活、凋亡、转化、细胞免疫等重要的生理病理过程。现已有研究证明,STAT3可以调控BMSCs骨向分化过程。综述STAT3对BMSCs骨向分化的影响及可能作用机制的最新研究进展。
Orthodontic tooth movement is a process of bone remodeling that is a dynamic balance of pressure-side bone resorption and tension-side bone formation. Osteoblasts, osteoclasts and other changes occur under the mechanical force. BMSCs with multidirectional differentiation potential are mechanosensitive cells. Under proper mechanical stimulation in vitro, the biological characteristics of BMSCs undergo functional changes and the best requirements of adaptive response to mechanical stimulation are as follows: Osteogenic differentiation, this process requires a variety of signaling molecules. As a transcription factor, signal transducers and activator of transcription 3 (STAT3) are involved in important physiological and pathological processes such as cell proliferation, differentiation, survival, apoptosis, transformation and cellular immunity. Now studies have shown that STAT3 can regulate BMSCs bone differentiation process. This review summarizes the effects of STAT3 on the bone differentiation of BMSCs and its possible mechanism.