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目的调查分析2003 2012年云南省凤庆县某村发生的不明原因猝死事件,为预防、控制类似事件提供借鉴。方法按国家和云南省联合制定的《云南不明原因猝死监测防治方案》进行事件调查和处置,收集流行病学、临床等资料,进行系统尸检、毒(药)物检测和病理研究。结果 2003 2012年,该县的15例不明原因猝死夏季发生于同镇同村委会的两村民小组,共8个无关家庭受累,均为青壮年农民,突然发病、突然死亡,临床表现无特异性;现场调查未能找到毒沟褶菌、毒物和药物等可疑暴露;两户3例尸检未发现相同的病理改变,其中2例多种常规毒(药)物检测阴性,1例毒沟褶菌毒素检测阴性。结论云南省凤庆县某村的不明原因猝死与毒沟褶菌无关,推测经口暴露于小范围内的可疑因素致家庭聚集性猝死。有必要对该村及附近的类似事件开展系统监测,深入调查研究。
Objective To investigate and analyze the sudden death of unknown cause occurred in a certain village in Fengqing County, Yunnan Province in 2012, and provide reference for the prevention and control of similar incidents. Methods According to the “Yunnan Unidentified Sudden Death Monitoring and Prevention Program” jointly formulated by Yunnan Province and Yunnan Province, the incident investigation and disposal were conducted. Epidemiological and clinical data were collected for systematic autopsy, drug and pathological studies. Results In 2003, 15 sudden unexplained sudden deaths occurred in the county in summer with two villagers’ groups in the same village with a total of 8 unrelated families, all of whom were young and middle-aged peasants. Sudden onset and sudden death showed no clinical manifestations The field investigation failed to find any suspicious exposure such as Toxophora, toxins and drugs. The same pathological changes were not found in 3 autopsies of two patients, of which 2 were negative for a variety of conventional drugs and 1 was for toxic furrows Mycotoxin test negative. Conclusion The sudden death of unidentified cause in a village of Fengqing County, Yunnan Province was not related to Pleurotus ostreatus. It is speculated that suspicious factors of oral exposure in a small area caused sudden death of family conglomeration. It is necessary to conduct systematic monitoring and investigation of similar incidents in and around the village.