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在癫痫的发病机理中,免疫机制假说,于1969年首先由Walker所提出.近来在两个方面的发现,这个假说从新又被提出来.首先,某些作者证实,用抗脑组织成份的抗血清局部用于动物脑皮层,可诱发出癫痫活动.其次,几例癫痫患者有免疫缺陷状态,这种现象,可能是部份表现对癫痫药物治疗的一种副作用,但也有抗癫痫治疗开始之前即有免疫缺陷.(一)实验性癫痫的自家免疫若体液免疫参与了癫痫灶的形成,可能是原发病灶释放脑抗原进入全身血循环引起的.几种脑抗原对于免疫器官来说是外源性的,因此引起抗体产生.冷冻动物局部脑皮层,是产生实验性癫痫的一种方法,这种方法能引起脑抗原释放至脑脊液.鞘内免疫法形成的抗体效价和普通免疫方法获得的效价
In the pathogenesis of epilepsy, the immune mechanism hypothesis was first proposed by Walker in 1969. This recent hypothesis has been revisited in two recent discoveries: First, some authors have demonstrated that anti-brain tissue components Serum local use in the animal’s cerebral cortex can induce seizure activity.Secondly, there are several cases of epilepsy in patients with immunodeficiency status, this phenomenon may be part of the performance of the epilepsy treatment of a side effect, but also before the start of anti-epileptic treatment Ie immunodeficiency (1) Self-immunity of experimental epilepsy If humoral immunity is involved in the formation of epileptic foci, the primary lesion may be caused by the release of brain antigens into the systemic circulation. Several brain antigens are exogenous to immune organs Thus resulting in antibody production.Calculation of the animal’s local cortex is a method of producing experimental epilepsy that causes the release of brain antigens to the cerebrospinal fluid.The antibody titers formed by intrathecal immunization and those obtained by conventional immunization potency