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借鉴广义二维相关光谱法,以温度为扰动进行待测化合物的中红外-近红外(IR-NIR)二维相关谱分析,利用IR光谱峰归属明确的特点,通过IR-NIR光谱的相关分析,确定NIR光谱中与待测化合物结构关联密切并受干扰程度较小的典型特征波数区域作为NIR特征谱段相关系数法中的特征谱段。据此快速建立的筛查中成药/保健品中非法添加枸橼酸西地那非、他达拉非和盐酸二甲双胍的NIR特征谱段相关系数法的准确性均在90%左右,可以满足现场快速筛查的需要。
By using generalized two-dimensional correlation spectroscopy, the mid-infrared (IR) -IRIR correlation analysis of the compounds under perturbation was carried out. The IR spectral peaks were attributed to the definite characteristics. The IR-NIR correlation analysis , The typical characteristic wave number region of NIR spectrum which is closely related to the structure of the tested compound and less disturbed is determined as the characteristic spectrum in the correlation coefficient method of NIR characteristic spectrum. According to this, the accuracy of the correlation coefficient method of NIR signature spectrum of illegally added sildenafil citrate, tadalafil and metformin hydrochloride in screening proprietary Chinese medicines / health supplements was about 90%, which could meet the needs of on-site Need for rapid screening.