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目的探讨血浆内源性阿片肽（Ｅｏｐ）在实验性肝硬变及腹水形成过程中的变化的意义．方法应用放射免疫法测定正常对照组及ＣＣｌ４诱发大鼠肝硬变（ｎ＝３７）及形成腹水（ｎ＝１７）过程中血浆３种Ｅｏｐ的含量变化．结果肝硬变腹水组及肝硬变组血浆亮氨酸脑啡肽（ＬＥＮＫ）含量均显著高于正常对照组（Ｐ均＜００１），且都与血清清蛋白浓度呈显著负相关（ｒ＝－０６９，Ｐ＜００１；ｒ＝－０５６，Ｐ＜００１）；与凝血酶原时间（ＰＴ）呈显著正相关（ｒ＝０６８，Ｐ＜００１；ｒ＝０６９，Ｐ＜００１）．同样两肝硬变组血浆强啡肽（ＤｙｎＡ１－１３）含量均显著高于正常对照组（Ｐ均＜００１）．且与血清清蛋白浓度呈显著负相关（ｒ＝－０６４，Ｐ＜００１；ｒ＝－０５９，Ｐ＜００１），与ＰＴ呈显著正相关（ｒ＝０６５，Ｐ＜００１；ｒ＝０６７，Ｐ＜００１）．但两肝硬变组血浆ＬＥＮＫ，ＤｙｎＡ１－１３与血ＡＬＴ不相关．β内啡肽（βＥＰ）的血浆含量在两肝硬变组及正常对照组中无显著差异．结论肝脏灭活功能受损是血浆小分子阿片肽（ＬＥＮＫ与ＤｙｎＡ１－１３）含量升高的重要原因，后者又是实验性肝硬变腹水形成的主要原因之一．而在β?
Objective To investigate the significance of plasma endogenous opioid peptide (Eop) in the process of experimental cirrhosis and ascites formation. Methods Radioimmunoassay was used to determine the plasma levels of three Eop in normal control group and CCl4-induced cirrhosis (n = 37) and ascites (n = 17). Results The levels of LENK in cirrhotic ascites group and cirrhosis group were significantly higher than those in normal control group (all P <001), and both of them were significantly negative with serum albumin (R = -0.69, P <001; r = -0.56, P <001), and prothrombin time (PT) showed a significant positive correlation (r = 0.68, P < 0 01; r = 0 69, P <0 01). The same two groups of cirrhosis plasma dynorphin (DynA1-13) were significantly higher than the normal control group (P all <0.01). (R = -064, P <001; r = -059, P <001), and had a significant positive correlation with PT (r = 065 , P <001; r = 067, P <001). But two cirrhosis group plasma L ENK, DynA1-13 and blood ALT is not related. β endorphin (β EP) plasma levels in the two cirrhosis group and the normal control group no significant difference. Conclusions Impairment of liver inactivation is an important reason for the increase of plasma small molecule opioid peptide (LENK and DynA1-13), which is one of the main reasons for the formation of liver cirrhosis ascites. In beta?