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脓毒症是导致DIC的首席病因。DIC是脓毒症导致多脏器功能衰竭(MOFF)的中间病理环节。然而两者皆以微血管为靶器官。此时因刺激(细菌内毒素)的强度与宿主的状态(遗传、代谢、免疫、内分泌)有别,其病理生理的变化与临床综合征的表达迥异。对其深入的了解无疑是诊断与治疗脓毒症与DIC的关键。
Sepsis is the leading cause of DIC. DIC is the intermediate pathological stage of sepsis leading to multiple organ failure (MOFF). However, both are microvessels as target organs. In this case, the intensity of the stimuli (bacterial endotoxin) is different from the state of the host (genetic, metabolic, immune, and endocrine), and its pathophysiological changes are very different from those of clinical syndromes. Its in-depth understanding is undoubtedly the key to diagnosis and treatment of sepsis and DIC.