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目的:探讨肝豆状核变性(HLD)患者的肝纤维化血清标志物:透明质酸(HA)、层粘蛋白(LN)和四型胶原(Ⅳ-C)的变化。方法:对186例HLD患者和39例正常对照组用放射免疫分析检测HA、LN和Ⅳ-C水平。结果:HLD组的HA、LN和Ⅳ-C水平分别为(175.12±73.81)μg/L、(128.60±21.36)μg/L和(87.98±32.74)μg/L显著高于正常对照组(P<0.01)。结论:HLD患者肝纤维化血清标志物水平显著升高,其均有不同程度的肝纤维化的存在。
Objective: To investigate the changes of serum fibrotic markers of liver fibrosis such as hyaluronic acid (HA), laminin (LN) and type Ⅳ collagen (Ⅳ-C) in patients with hepatolenticular degeneration (HLD) Methods: The levels of HA, LN and Ⅳ-C were detected by radioimmunoassay in 186 HLD patients and 39 normal controls. Results: The levels of HA, LN and Ⅳ-C in HLD group were (175.12 ± 73.81) μg / L, (128.60 ± 21.36) μg / L and (87.98 ± 32.74) μg / L, respectively) 0.01). Conclusions: Serum markers of liver fibrosis in patients with HLD are significantly elevated, and all have different degrees of hepatic fibrosis.