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虽然在其他国家中,在密切监督下,主要以每周2次短程化疗治疗结核病已证明是有效的,但是在美国大多数病人都是老年人和多是在门诊治疗,这种疗法没有被采用。在美国小直布罗陀阿肯色州保健部门结核病规划办公室为中心的领导下,从1976年1月起对315例新发现、痰菌阳性证实为肺结核的病人,每日予利福平600mg,异烟肼300mg治疗1个月,以后改为利福平600mg,异烟肼900mg每周2次治疗8个月。除了少数病人外,均为自己服药。经治疗3个月后,有95%病人痰培养阴转。185例完成疗程的病人中,仅有10例治疗失败。175例治疗后随访1～21个月间,仅有1例复发。很少有严重的副作用:6例有黄疸,2例有“感冒样综合征”,1例有血小板减少。这篇报告是美国首次详细的结核病短程化疗报告。在本研究的计划中,利用少于100个剂量的利福
Although in other countries tuberculosis has been shown to be effective mainly with twice-weekly short-course chemotherapy under close scrutiny, the majority of patients in the United States are elderly and are mostly treated in outpatient settings and this treatment is not used . Under the leadership of the Tuberculosis Planning Office of the Arkansas Department of Health in Gibraltar in the United States, from January 1976 onwards, 315 newly diagnosed cases of sputum bacilli were confirmed as pulmonary tuberculosis with daily doses of 600 mg of rifampicin and 300 mg of isoniazid Treatment for 1 month, later changed to rifampicin 600mg, isoniazid 900mg twice weekly for 8 months. In addition to a small number of patients, all for their own medication. After 3 months of treatment, 95% of patients sputum culture Yin turn. Of the 185 patients who completed the course of treatment, only 10 failed. 175 cases were followed up for 1 ~ 21 months, only 1 case of recurrence. There are seldom serious side effects: jaundice in 6, flu-like syndrome in 2, and thrombocytopenia in 1. This report is the first report of the United States on short-course TB treatment. In the study’s plan, less than 100 doses of Rifab were used