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目的:观察小剂量环磷酰胺(CTX)冲击联合激素治疗狼疮性肾炎(LN)的疗效及其安全性。方法:将54例LN患者随机分为三组,A组18例激素治疗,B组18例行小剂量CTX冲击联合激素治疗,C组18例大剂量CTX冲击联合激素治疗进行回顾性分析。结果:治疗9个月后,近期疗效B组与C组明显优于A组。复发次数A组>C组>B组,不良反应C组>B组>A组,46例患者无一例出现不可逆或致死性不良反应。结论:小剂量CTX冲击联合激素治疗LN可显著增加疗效,不易复发,且不良反应相对较少。
Objective: To observe the efficacy and safety of low dose cyclophosphamide (CTX) combined with hormonal treatment of lupus nephritis (LN). Methods: 54 cases of LN patients were randomly divided into three groups, 18 cases in group A were treated with hormones, 18 cases in group B were treated with low-dose CTX combined with hormones, and 18 cases in group C were treated with high-dose CTX combined with hormonal therapy. Results: After 9 months of treatment, the recent curative effects of group B and group C were better than group A. The number of relapse A group> C group> B group, adverse reaction C group> B group> A group, 46 patients without adverse or irreversible adverse reactions. Conclusion: Small dose CTX combined with hormone therapy can significantly increase the efficacy of LN, not easy to relapse, and the adverse reaction is relatively small.