论文部分内容阅读
目的探讨胃癌根治术后腹腔灌注化疗联合全身静脉化疗对免疫功能和预后的影响。方法选取2008年2月至2012年2月间收治的胃癌患者120例,按照随机数字表法分为观察组和对照组,每组60例。观察组患者术后行全身静脉化疗联合腹腔化疗,对照组患者仅给予全身静脉化疗,比较两组患者T细胞亚群、卡氏体力状态(KPS)评分、肿瘤复发率及生存率情况。结果观察组患者治疗后CD4~+、CD4~+/CD8~+水平与对照组比较,差异无统计学意义(P>0.05);观察组患者2、3年生存率明显高于对照组(P<0.05),术后肿瘤复发率明显低于对照组(P<0.05);观察组患者KPS评分有效率高于对照组,差异有统计学意义(P<0.05)。结论胃癌根治术后辅助全身静脉化疗并联合腹腔区域性化疗,可降低胃癌复发率、提高患者生存率、改善患者的体力状况和生存质量,值得临床推广。
Objective To investigate the effect of intraperitoneal chemotherapy combined with systemic intravenous chemotherapy on immune function and prognosis after radical operation of gastric cancer. Methods A total of 120 patients with gastric cancer who were admitted from February 2008 to February 2012 were divided into observation group and control group according to the random number table method, with 60 cases in each group. The patients in the observation group were treated with intravenous chemotherapy combined with intraperitoneal chemotherapy after operation. The patients in the control group were given only systemic intravenous chemotherapy. The T cell subsets, Karnofsignature state (KPS) score, tumor recurrence rate and survival rate were compared between the two groups. Results There was no significant difference in the levels of CD4 ~ + and CD4 ~ + / CD8 ~ + between the observation group and the control group (P> 0.05). The 2-year and 3-year survival rates in the observation group were significantly higher than those in the control group <0.05). The recurrence rate of postoperative tumor was significantly lower than that of control group (P <0.05). The effective rate of KPS score in observation group was higher than that in control group (P <0.05). Conclusions Auxiliary systemic chemotherapy combined with regional peritoneal chemotherapy after radical operation of gastric cancer can reduce the recurrence rate of gastric cancer, improve the survival rate of patients and improve their physical status and quality of life, which is worthy of clinical promotion.