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目的探讨局部注射他汀类药物在实验性牙齿移动中对骨改建的作用及比较辛伐他汀与阿伐他汀的作用有何不同。方法选取48只雄性SD大鼠,随机分为辛伐他汀组(A组)、阿伐他汀组(B组)、阴性对照组(C组)和基本对照组(D组),牵引其上颌第一磨牙近中移动,21d后拆除牵引装置,A组和B组在右上第一磨牙颊侧黏骨膜下注射0.1ml药物,C组注射同等量生理盐水,D组不注射任何药物,每天1次,分别观察3、7、14d上颌第一磨牙复发的距离。结果 3d时各组无明显差异(均P>0.05);7d时两实验组复发距离明显短于两对照(P<0.05),但B组与A组相比无明显差异(P>0.05);14d时两实验组复发距离明显短于两对照组(P<0.05),且B组明显短于A组(P<0.05)。结论局部注射他汀类药物能有效抑制正畸牙的复发,且随注射药物时间的延长阿伐他汀作用要优于辛伐他汀。
Objective To investigate the effect of local injection of statins on bone remodeling during experimental tooth movement and to compare the effects of simvastatin and atorvastatin. Methods Forty eight male Sprague-Dawley rats were randomly divided into simvastatin group (group A), atorvastatin group (group B), negative control group (group C) and basic control group (group D) A molar removal of the traction device 21d after removal of the traction device, group A and B in the buccal mucosa of the right upper first molar injection of 0.1ml drugs, C group injected with the same amount of saline, D group did not inject any drugs, 1 times a day, The distance of maxillary first molar recurrence was observed at 3, 7 and 14 days respectively. Results There was no significant difference in each group between the three groups (all P> 0.05). At 7 days, the relapse distance between the two experimental groups was significantly shorter than that of the two control groups (P <0.05). However, there was no significant difference between the two groups (P> 0.05). The relapse distance of the two experimental groups was significantly shorter than that of the two control groups on the 14th day (P <0.05), and the length of the two groups was significantly shorter than that of the A group (P <0.05). Conclusion Local injection of statins can effectively inhibit the recurrence of orthodontic teeth, and the effect of atorvastatin is better than simvastatin with prolonged injection time.