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目的研究洛阳地区健康妊娠中期妇女的甲状腺激素参考值范围,为诊断和治疗以及监测或者筛查孕妇甲状腺疾病以及相关研究提供参考。方法用化学发光免疫测定方法分别测定洛阳地区222例妊娠中期健康妇女甲状腺功能三项[血清游离三碘甲腺原氨酸(FT3)和血清游离甲状腺素(FT4)及促甲状腺激素(TSH)]水平,分别建立各项指标参考值范围。结果以中位数(M值)及双侧限值(P2.5和P97.5)表示妊娠中期妇女甲状腺激素的参考值范围,结果显示妊娠中期妇女FT3参考值范围较本院使用的参考值范围窄,妊娠中期妇女FT4和TSH参考值范围均低于本院使用的参考值范围。且以27岁为界,两组FT4水平差异有统计学意义(P<0.05),其他两项差异无统计学意义(P>0.05)。结论妊娠中期妇女的甲状腺激素参考值范围与正常人参考值范围存在差别,建立孕期甲状腺激素参考值范围及进一步研究建立不同年龄段甲状腺激素参考值范围是非常必要的。
Objective To study the reference value of thyroid hormone in healthy pregnant women in mid-term of Luoyang, and to provide reference for the diagnosis and treatment of thyroid hormone in pregnant women and the related research. Methods Chemiluminescence immunoassay was used to determine the thyroid function in 222 pregnant women in middle third trimester of pregnancy [serum free triiodothyronine (FT3), serum free thyroxine (FT4) and thyroid stimulating hormone (TSH)] respectively. Level, respectively, to establish the reference range of the indicators. Results Median (M) and bilateral limits (P2.5 and P97.5) showed the reference range of thyroid hormones in mid-pregnancy women. The results showed that the FT3 reference range in mid-pregnancy women was higher than the reference value used in our hospital Narrow range, mid-pregnancy women FT4 and TSH reference range are lower than the reference range used in this hospital. At the age of 27 years, there was a significant difference in FT4 levels between the two groups (P <0.05). The other two differences were not statistically significant (P> 0.05). Conclusions There is a difference between the reference value of thyroid hormone in pregnant women and the reference value of normal people in the second trimester of pregnancy. It is necessary to establish the reference value of thyroid hormone during pregnancy and to establish the reference value of thyroid hormone at different ages.