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丹参和肌苷对实验兔肾近曲小管上皮细胞具有相似的保护作用。在热缺血60min和120min后,该处微绒毛和线粒体的缺血性损害比对照组兔为轻。但用肌苷保护的肾小管间毛细血管内皮细胞的缺血性损害比用丹参保护的要重。缺血肾恢复血流30min后,丹参与肌苷两组的微绒毛和线粒体均基本恢复正常,而对照组的这些结构未能恢复正常。丹参的主要作用之一,可能与提供维持近曲小管细胞的微绒毛有规则地排列,以及修复热缺血期间引起的局部损害所需的能量有关。
Salvia miltiorrhiza and inosine have similar protective effects on proximal tubular epithelial cells in experimental rabbits. After 60 min and 120 min of warm ischemia, the ischemic lesions of microvilli and mitochondria were lighter than those of the control rabbits. However, the ischemic damage of intertubular capillary endothelial cells protected by inosine is heavier than that protected by Salvia miltiorrhiza. After 30 min of blood flow in the ischemic kidney, the microvilli and mitochondria of Dan in the inosine group both returned to normal, but these structures in the control group did not return to normal. One of the main effects of Salvia miltiorrhiza may be related to the regular arrangement of microvilli to provide maintenance of proximal tubule cells, as well as the energy required to repair local lesions caused during warm ischemia.