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巴西利什曼原虫引起的粘膜利什曼病既使用最大剂量的五价锑剂治疗也难痊愈。现场研究发现,5％的病人死于呼吸道阻塞和吸入性肺炎。其二线治疗药物是传统的两性霉素。AmBisome是一种对治疗内脏利什曼病有效的脂质体连接的两性霉素B。对6例锑酸葡胺(Glucantime)治疗无效的急性粘膜肉芽肿男性病人使用此药。此6例病人利什曼素皮内试验为阳性;间接荧光抗体试验中抗
Leishmaniasis-causing mucosal leishmaniasis is refractory to both treatment with the largest dose of pentavalent antimony. Field study found that 5% of patients died of airway obstruction and aspiration pneumonia. The second-line treatment is traditional amphotericin. AmBisome is a liposome-linked amphotericin B that is effective for the treatment of visceral leishmaniasis. The drug was used in 6 male patients with acute mucosal granuloma who failed to respond to glucantime. The 6 patients were positive for Leishman’s intradermal test; anti-indirect fluorescent antibody test