论文部分内容阅读
为建立西安地区孕妇妊娠早期（T1期）、中期（T2期）、晚期（T3期）甲状腺功能指标的参考区间。本研究采用横断面研究的方法，通过调查问卷共招募表观健康的620名孕妇，采用全自动化学发光分析仪检测血清促甲状腺激素（TSH）、总三碘甲状腺原氨酸（TT3）、总甲状腺激素（TT4）、游离三碘甲状腺原氨酸（FT3）和游离甲状腺激素（FT4）水平，并且使用新一代TSH检测试剂（3rd IS），以探讨妊娠期特异性甲状腺功能指标的参考区间。结果显示，T1期、T2期和T3期TSH的参考区间分别是0.05~4.59 mIU/L、0.61~6.01 mIU/L、0.63~4.78 mIU/L；TT3是1.62~2.97 nmol/L、1.59~2.95 nmol/L、1.45~2.70 nmol/L；TT4是95.49~185.00 nmol/L、92.70~181.54 nmol/L、77.93~155.09 nmol/L；FT3是3.18~5.22 pmol/L、2.78~4.67 pmol/L、2.51~4.18 pmol/L；FT4是7.72~12.97 pmol/L、6.90~11.09 pmol/L、5.63~9.85 pmol/L。所有甲状腺功能指标在不同孕期之间差异均有统计学意义（TSH：n H=30.879，n P<0.01；FT3：n H =153.827，n P<0.01；FT4：H =229.967，n P<0.01；TT3：n H =36.484，n P<0.01；TT4：n H =58.531，n P<0.01）。分别收集20例独立样本对妊娠3个期的TSH、FT3、FT4、TT3、TT4的参考区间进行验证，全部验证通过。n “,”To establish reference intervals for thyroid functional indicators in early (T1), mid-term (T2), and late stage (T3) pregnancy in a population of women in Northwestern China. A cross-sectional study was conducted on 620 pregnant women. Subjects were recruited through a questionnaire where apparently healthy women were selected. Serum thyroid stimulating hormone (TSH3), total triiodothyronine (TT3), total thyroid hormone (TT4), free triiodothyronine (FT3), and free thyroid hormone (FT4) were detected using the Beckman Unicel DXI 800 automatic chemiluminescence analyzer (the third-generation TSH detection reagent for TSH3),and the reference intervals of different gestation periods were established. The results showed that the reference intervals of TSH3 in T1, T2, and T3 were 0.05-4.59, 0.61-6.01, and 0.63-4.78 mIU/L, respectively; TT3 were 1.62-2.97 nmol/L, 1.59-2.95 nmol/L, and 1.45-2.70 nmol/L, respectively; TT4 were 95.49-185.00 nmol/L, 92.70-181.54 nmol/L, and 77.93-155.09 nmol/L, respectively; FT3 were 3.18-5.22 pmol/L, 2.78-4.67 pmol/L, and 2.51-4.18 pmol/L, respectively; and FT4 were 7.72-12.97 pmol/L, 6.90-1.09 pmol/L, and 5.63-9.85 pmol/L, respectively. All thyroid function indexes had statistically significant differences between the three stages of pregnancy (TSH:n H=30.879,n P<0.01;FT3:n H =153.827,n P<0.01;FT4:n H =229.967,n P<0.01;TT3:n H =36.484,n P<0.01;TT4:n H =58.531,n P<0.01). 20 independent samples were collected to verify the reference intervals of TSH, FT3, FT4, TT3 and TT4 for three trimesters of pregnancy, and all of them passed.n