Osteopontin knockdown suppresses the growth and angiogenesis of colon cancer cells

• 作 者: Xin-Lin Wu Kai-Jin Lin Ai-Ping
• 机 构: DepartmentofGeneralSurgery,DepartmentofInternalMedicine,DepartmentofGastroenterology,ClinicalMedicin
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2014年30期
• 关键词: COLON carcinoma LOVO cells OSTEOPONTIN Angiogenesi Colon carcinoma Lovo cells Os
• 基金项目: Grants from the National Natural Science Foundation of China,No.81260364,No.81270472 and No.81070310,the“Chunhui”Program of Ministry of Education in China,No.Z2012007,the Natural Science Foundation of

AIM:To investigate the effects of osteopontin(OPN)gene expression knockdown on colon cancer Lovo cells in vitro.METHODS:Four candidate small interfering RNA(siRNA)constructs targeting the OPN gene and a scrambled control sequence(NC-siRNA)were synthesized