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目的:探讨甲氨蝶呤和米非司酮联合治疗未破裂型异位妊娠的效果。方法:A组:米非司酮50mg口服每日2次,连用4天,甲氨蝶呤50mg/m2肌肉注射每日1次;B组:米非司酮50mg口服每日2次,连用4天。观察患者自觉症状、一般情况、血β-HCG浓度和B超检查,直至正常。结果:A组治愈率高于B组,两组比较差异有显著性(P<0.05)。A组血β-HCG降至正常时间、包块缩小和症状消失时间均短于B组,两组比较差异有极显著性。结论:米非司酮联合甲氨蝶呤治疗未破裂型异位妊娠安全、有效。
Objective: To investigate the effect of combination of methotrexate and mifepristone on unruptured ectopic pregnancy. Methods: Group A: Mifepristone 50mg orally 2 times a day, once every 4 days, methotrexate 50mg / m2 intramuscularly once a day; Group B: mifepristone 50mg orally 2 times a day, once every 4 day. Observe the patient’s symptoms, the general situation, blood β-HCG concentration and B-ultrasound until normal. Results: The cure rate of group A was higher than that of group B, the difference was significant (P <0.05). A group of blood β-HCG decreased to normal time, mass shrinkage and disappearance of symptoms were shorter than the B group, the difference between the two groups was significant. Conclusion: Mifepristone combined with methotrexate is safe and effective in the treatment of unruptured ectopic pregnancy.