An efficient method for preparing the sphingosine-1-phosphate receptor agonist, KRP203-phosphate

• 作 者: Xiao-Jian Wang Jian-Guo Qi Gang Li Yu-Lin Tian Da-Li Yin
• 机 构: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laborat
• 出 处: Chinese Chemical Letters
• 发表日期: 2013年09期
• 关键词: agonist preparing tradition analogs pleased donor benzyl spectrometer erythemato

An efficient method for mono-phosphorylation of 2(KRP203)using cbz-protection,dibenzylphosphoryl chloride and TMSI affording 2-P(KRP203-P)was developed.We applied the present method to the synthesis of KRP203 phosphate analogs which were difficult to produce through tradition procedures.

An efficient method for mono-phosphorylation of 2 (KRP203) using cbz-protection, dibenzylphosphoryl chloride and TMSI affording 2-P (KRP203-P) was developed. We applied the present method to the synthesis of KRP203 phosphate analogs which were difficult to produce through tradition procedures.