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目的:分析早产儿侵袭性真菌感染(IFI)的高危因素,为其及时有效诊治提供依据。方法:对该院2009年1月1日~2011年12月31日期间住院的3 520例早产儿中确诊为真菌感染的104例患儿进行回顾性研究,分析真菌感染的高危因素。结果:3年间该院真菌感染的总发生率为2.95%,排前三位的月份为1月、8月和10月;出生体重(BW)<1 000 g、1 000~1 499 g、1 500~2 499 g、2 500~4 000 g的早产儿IFI发生率依次为1.67%、7.85%、2.64%、0.84%;胎龄(GA)<28周、28~31+6周、32~36+6周早产儿IFI发生率为5.26%、8.38%、1.49%;辅助通气及使用脂肪乳时间是真菌感染的独立危险因素。结论:低出生体重儿、夏秋冬季、广谱抗生素、辅助通气及胃肠道外营养等是早产儿真菌感染的高危因素。
Objective: To analyze the risk factors of invasive fungal infection (IFI) in premature infants and provide the basis for timely and effective diagnosis and treatment. Methods: A total of 104 infants diagnosed as fungal infections in 3 520 preterm infants hospitalized from January 1, 2009 to December 31, 2011 in our hospital were retrospectively analyzed. The risk factors for fungal infection were analyzed. Results: The total incidence of fungal infections in this hospital was 2.95% in three years. The top three months were January, August and October. The birth weight (BW) was less than 1 000 g, 1 000-1 499 g, 1 The prevalence of IFI in preterm infants of 500-2499 g and 2500-5000 g were 1.67%, 7.85%, 2.64% and 0.84%, respectively. The gestational age (GA) <28 weeks, 28-31 + 6 weeks, The prevalence of IFI in preterm infants at 36 + 6 weeks was 5.26%, 8.38% and 1.49%, respectively. Supplementary ventilation and fat emulsion time were independent risk factors for fungal infection. Conclusion: Low birth weight children, summer and fall winter, broad-spectrum antibiotics, assisted ventilation and parenteral nutrition are risk factors of fungal infection in preterm infants.