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Crude decoction, aqueous and ethanolic extracts of two medicinal plants (Psidium guajava and Diospyros mespili- formis), widely used in the central plateau of Burkina Faso to treat many diseases were evaluated for their antagonistic effects on caffeine induced calcium release from sarcoplasmic reticulum of rat skeletal muscle cells. These different extracts showed a decrease of caffeine induced calcium release in a dose dependent manner. Comparison of the results showed that Psidium guajava leaf extracts are more active than extracts of Diospyros mespiliformis and that crude decoctions show better inhibitory activity. The observed results could explaine their use as antihypertensive and antidiarrhoeal agents in traditional medicine, by inhibiting intracellular calcium release.
Crude decoction, aqueous and ethanolic extracts of two medicinal plants (Psidium guajava and Diospyros mespili- formis), widely used in the central plateau of Burkina Faso to treat manycies were evaluated for their antagonistic effects on caffeine induced calcium release from sarcoplasmic reticulum of rat The observations show that the PDDium guajava leaf extracts are more active than extracts Results could explaine their use as antihypertensive and antidiarrhoeal agents in traditional medicine, by inhibiting intracellular calcium oxide release.