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在我国海南岛的抗氯喹恶性疟流行区,应用300mg蒿甲醚油剂肌注,同时口服周效磺胺1,000mg、乙胺嘧啶70mg和伯喹30mg的伍用单剂治疗方案(简称ASPP),治疗54例抗氯喹恶性疟现症患者。并与32例用蒿、周、乙伍用单剂(简称ASP)和25例用青(青蒿素500mg肌注)、周、乙、伯伍用单剂(简称QSPP)治疗的患者进行比较:以50例单用氯喹标准剂量1,500mg三天疗法(简称CQ)组为对照。发现在控制症状和清除原虫无性体方面,以ASPP与ASP的速度最快,QSPP次之,CQ最慢;在配子体消失时间上,没有伍用伯喹的ASP和CQ组的效果均不满意;观察35天,ASPP、ASP和QSPP治疗的患者均获治愈,CQ组50例的治愈率仅18％。
In our country Hainan Island anti-chloroquine falciparum malaria endemic area, the application of 300mg artemether oil intramuscular injection, while oral administration of sulfamethoxazole 1,000mg, pyrimethamine 70mg and primary quinine 30mg single-agent treatment program (referred to as ASPP) Treatment of 54 cases of anti-chloroquine falciparum malaria patients. And compared with 32 patients treated with a single dose of Artemisia, Zhou, B Wu with a single dose (referred to as ASP) and 25 cases of green (artemisinin 500mg intramuscular injection), weeks, B, : 50 cases of chloroquine standard dose of 1,500 mg three days therapy (referred to as CQ) group as a control. It was found that in the control of symptoms and elimination of protozoan asexuals, ASPP and ASP were the fastest, followed by QSPP and CQ the slowest. In the disappearance time of gametophyte, the effects of ASP and CQ without pentobarbital were not satisfied; After 35 days of observation, patients treated with ASPP, ASP and QSPP were cured. The cure rate of 50 cases in CQ group was only 18%.