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近数十年来,对口服维甲酸类药物进行了广泛的实验和临床研究,特别是一些新合成的维甲酸类药物,如芳香性维甲酸对一些以往难以治疗的皮肤病如脓疱性银屑病、毛囊角化症和鱼鳞病等获得良好疗效,在皮肤病的怡疗学上又开辟了一个新的领域。 一、引言 自1947年化学合成VitA,并应用以治疗痤疮、银屑病、鱼鳞病等皮肤病获得了疗效。但当需要大剂量应用时,常因VitA过多症的产生而不得不停用。于是人们开始研究寻找更有效、耐受好的VitA
In recent decades, a wide range of experimental and clinical studies on oral retinoid drugs, in particular, some new synthetic retinoids, such as aromatic retinoic acid for some previously difficult to treat the skin diseases such as pustular psoriasis The disease, follicular keratosis and ichthyosis get good curative effect, which opens up a new field in dermatology. First, the introduction Since 1947 chemical synthesis of VitA, and applied to treat acne, psoriasis, ichthyosis and other skin diseases obtained the curative effect. However, when the need for high-dose applications, often due to excessive production of VitA had to be disabled. So people began to look for more effective, well-tolerated VitA