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目的探讨冠心病治疗中口服抗血小板药物的疗效。方法选取2014年5月~2015年1月我中心收治的冠心病患者130例为研究对象,随机分为对照组与研究组,各65例。对照组患者在常规治疗的同时给予硫酸氯吡格雷片口服治疗;研究组在常规治疗的同时给予普拉格雷片口服治疗。对两组患者的疗效、不良反应、血小板反应指数、血小板聚集率进行统计分析。结果观察组治疗有效率显著高于对照组,不良反应发生率显著低于对照组,差异均有统计学意义(P<0.05);观察组血小板反应指数(PRI)及血小板聚集率(MPA)改善情况显著优于对照组,差异有统计学意义(P<0.05)。结论对冠心病患者在常规治疗基础上给予抗血小板药物口服治疗,可取得良好的疗效,且不良反应少,值得临床推广。
Objective To investigate the efficacy of oral antiplatelet drugs in the treatment of coronary heart disease. Methods From May 2014 to January 2015, 130 patients with coronary heart disease admitted to our center were selected as study subjects and randomly divided into control group and study group, with 65 cases in each group. Patients in the control group were given oral treatment with clopidogrel sulfate tablets routinely while patients in the study group were treated with prasugrel tablets routinely. The curative effect, adverse reaction, platelet response index and platelet aggregation rate of two groups were statistically analyzed. Results The effective rate of observation group was significantly higher than that of control group, and the incidence of adverse reactions was significantly lower than that of control group (P <0.05). The platelet response index (PRI) and platelet aggregation rate (MPA) of observation group were improved The situation was significantly better than the control group, the difference was statistically significant (P <0.05). Conclusion Oral treatment of patients with coronary heart disease on the basis of conventional treatment of antiplatelet drugs, can achieve good results, and fewer adverse reactions, is worth clinical promotion.