论文部分内容阅读
阿斯匹林(ASP)的主要药理机制是抑制前列腺素(PG)合成和促使组织生化反应中的氧化磷酸化解偶联。因此除对相应疾病的病理过程产生有益作用外,亦可对机体的正常代谢功能产生不利影响。随着用量、疗程的差异,机体代谢亦呈现复杂效应。本文拟就此问题试加讨论,希冀对ASP的合理应用有所裨益。 1.水盐代谢:目前认为,PG对调节肾脏代谢,增加肾脏血供重要作用,并可拮抗肾素—血管紧张素—醛固酮(RAA)系统及钠利尿激素作用。ASP通过对过氧化物酶的抑制和乙酰化蛋白作用,使肾局部血流量减少,肾小球滤过率(GFR)降低,肾素和醛固酮分泌增多,尿量减少,钠水同时潴留,同时通过抗
The primary pharmacological mechanism of aspirin (ASP) is the inhibition of prostaglandin (PG) synthesis and the uncoupling of oxidative phosphorylation in tissue biochemical reactions. Therefore, in addition to the beneficial effects of the pathological process of the corresponding diseases, it can also adversely affect the normal metabolism of the body. With the dosage, treatment differences, the body metabolism also showed a complex effect. This article intends to try to discuss this issue, hoping to benefit the rational use of ASP. 1. Water and salt metabolism: At present it is thought that PG plays an important role in regulating renal metabolism and increasing renal blood supply, and antagonizes the action of renin-angiotensin-aldosterone (RAA) system and sodium diuretic hormone. ASP through the inhibition of peroxidase and acetylation of protein, the renal local blood flow decreased glomerular filtration rate (GFR) decreased, increased secretion of renin and aldosterone, decreased urine output, sodium and water retention at the same time Through the anti