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目的观察中西药联合治疗难治性高血压的临床效果。方法将难治性高血压患者60例,按照随机数字表法分为试验组与对照组各30例。对照组给以贝那普利+氨氯地平+氢氯噻嗪治疗;试验组在对照组基础上加用中药石决牡蛎汤治疗。比较2组临床疗效,治疗前后的血压水平变化(收缩压、舒张压分别测量3次后取平均值),以及治疗后患者的实验室指标(以血糖、肌酐、胆固醇、三酰甘油)。结果试验组治疗总有效率为83.3%高于对照组的60.0%,差异有统计学意义(χ~2=4.021,P<0.05)。治疗后,2组收缩压、舒张压较治疗前均有所改善,且试验组低于对照组,差异均有统计学意义(P<0.05)。治疗后2组的血糖、肌酐、胆固醇、三酰甘油等指标比较差异无统计学意义(P>0.05)。结论难治性高血压在临床上使用常规西药联合中药石决牡蛎汤治疗能够提高降压效果,且无明显不良反应值得临床推广。
Objective To observe the clinical effect of combined treatment of traditional Chinese and western medicine on refractory hypertension. Methods 60 patients with refractory hypertension were divided into experimental group and control group according to the random number table method, 30 cases each. The control group was treated with benazepril + amlodipine + hydrochlorothiazide; the experimental group was treated with Shi Dan Oyster Soup on the basis of the control group. The clinical curative effect was compared between the two groups. The changes of blood pressure before and after treatment (mean systolic blood pressure and diastolic blood pressure were measured after 3 times) and the laboratory indexes (including blood sugar, creatinine, cholesterol and triglyceride) of patients after treatment were compared. Results The total effective rate of the experimental group was 83.3%, which was significantly higher than that of the control group (χ ~ 2 = 4.021, P <0.05). After treatment, systolic blood pressure and diastolic blood pressure were improved in both groups, and the experimental group was lower than the control group, the difference was statistically significant (P <0.05). There was no significant difference in blood glucose, creatinine, cholesterol and triglyceride between the two groups after treatment (P> 0.05). Conclusion Refractory hypertension in clinical use of traditional Chinese medicine combined with Chinese medicine stone decoction oyster soup can enhance the antihypertensive effect, and no adverse reactions worthy of clinical promotion.